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Issue 69, 2017, Issue in Progress
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Magnetization of eugenol to fabricate magnetic-responsive emulsions for targeted delivery of caffeic acid phenethyl ester

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Abstract

Fabrication of manipulative colloidal vehicles with appreciable stability under an eco-friendly, cross-linkage free environment has long been one of the major challenges in targeted delivery for curative, acoustic, and imaging purposes. A new targeted delivery system was developed in this paper based on magnetization of eugenol with magnetic Fe3O4 nanoparticles by simply evaporating water from the 3-phase system prior to a one-step coating of the oil using rice proteins to form core/shell structured composites. The droplets, examined as well-defined spheres with a mean hydrodynamic diameter of 204 nm, were metastable against long-term storage for up to 4 months, thermal treatment for up to 90 °C and UV (365 nm) radiation for up to 24 h. Furthermore, upon an external manipulation, the magnetic emulsions enhanced the anti-proliferation effects of encapsulated CAPE, an anti-cancer drug, on HCT-116 cells by over 20% compared to CAPE encapsulated in normal emulsions at dosages of 0.2 and 2 μg mL−1. In principle, a wide variety of o/w emulsions can be magnetized using this approach. As a first step towards magnetic delivery, magnetization of oil may become a new targeted delivery strategy in the development of future site-specific diagnosis and treatment.

Graphical abstract: Magnetization of eugenol to fabricate magnetic-responsive emulsions for targeted delivery of caffeic acid phenethyl ester

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Publication details

The article was received on 24 Jul 2017, accepted on 03 Sep 2017 and first published on 08 Sep 2017


Article type: Paper
DOI: 10.1039/C7RA08167G
RSC Adv., 2017,7, 43455-43463
  • Open access: Creative Commons BY license
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    Magnetization of eugenol to fabricate magnetic-responsive emulsions for targeted delivery of caffeic acid phenethyl ester

    T. Wang, R. Wang, Z. Chen and Q. Zhong, RSC Adv., 2017, 7, 43455
    DOI: 10.1039/C7RA08167G

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