Jump to main content
Jump to site search

Issue 2, 2017
Previous Article Next Article

Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

Author affiliations

Abstract

This article presents the preparation and in vitro biological activities of new 5′-arylchalcogeno-3-aminothymidine derivatives as antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.

Graphical abstract: Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Nov 2016, accepted on 16 Dec 2016 and first published on 22 Dec 2016


Article type: Research Article
DOI: 10.1039/C6MD00640J
Citation: Med. Chem. Commun., 2017,8, 408-414
  •   Request permissions

    Synthesis, antioxidant and antitumoral activities of 5′-arylchalcogeno-3-aminothymidine (ACAT) derivatives

    R. M. da Rosa, B. C. Piccoli, F. D. da Silva, L. Dornelles, J. B. T. Rocha, M. S. Sonego, K. R. Begnini, T. Collares, F. K. Seixas and O. E. D. Rodrigues, Med. Chem. Commun., 2017, 8, 408
    DOI: 10.1039/C6MD00640J

Search articles by author

Spotlight

Advertisements