Light-responsive CO2 bubble-generating polymeric micelles for tumor cell ablation

Yifan Zhang; Yuncai Guan; Sizhan Ge; Ahu Yuan; Jinhui Wu; Yiqiao Hu

doi:10.1039/C6MD00625F

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Light-responsive CO₂ bubble-generating polymeric micelles for tumor cell ablation†‡

Yifan Zhang,§^a Yuncai Guan,§^a Sizhan Ge,^a Ahu Yuan,^acde Jinhui Wu

*^abcde and Yiqiao Hu*^acde

Author affiliations

* Corresponding authors

^a State Key Laboratory of Pharmaceutical Biotechnology, Medical School of Nanjing University, Nanjing 210093, China
E-mail: wuj@nju.edu.cn, huyiqiao@nju.edu.cn

^b State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

^c Institute of Drug R&D, Medical School of Nanjing University, Nanjing 210093, China

^d Jiangsu R&D platform for controlled & targeted drug delivery, Nanjing University, Nanjing 210093, China

^e Jiangsu Key Laboratory for Nano Technology, Nanjing University, Nanjing 210093, China

Abstract

We report a novel UV-responsive polymeric micelle system based on coumarin ester for tumor treatment. The micelle itself can generate CO₂ under UV exposure owing to the photolysis of (7-diethylaminocoumarin-4-yl)methyl (DEACM). Without loading any drugs, the micelle causes significant cell death under 8 s UV irradiation in vitro. This is the first time to use light to decompose the nano-carrier itself into CO₂ bubbles for tumor cell ablation.

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Article information

DOI: https://doi.org/10.1039/C6MD00625F
Article type: Research Article
Submitted: 09 Nov 2016
Accepted: 15 Dec 2016
First published: 09 Jan 2017

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Med. Chem. Commun., 2017,8, 405-407

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Light-responsive CO₂ bubble-generating polymeric micelles for tumor cell ablation

Y. Zhang, Y. Guan, S. Ge, A. Yuan, J. Wu and Y. Hu, Med. Chem. Commun., 2017, 8, 405 DOI: 10.1039/C6MD00625F

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