Metal- and oxidant-free S–P(O) bond construction via direct coupling of P(O)H with sulfinic acids

Abstract

We have developed a simple and convenient method for S–P(O) bond formation between R₂P(O)H and sulfinic acids under metal-, oxidant-, and halogen-free conditions. The current method is compatible with a broad range of substituents on various substrates including halogens and heterocyclic moieties. The synthetic potential of this method was further highlighted by the expeditious synthesis of optically active P-chiral phosphorothioates via stereospecific coupling.