Issue 49, 2017
From the journal:

Chemical Communications

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets†

Ye-Jin Hwang,‡ab   Connor W. Coley, ORCID logo ‡a   Milad Abolhasani, ORCID logo c   Andreas L. Marzinzik,d   Guido Koch,d   Carsten Spanka, ORCID logo d   Hansjoerg Lehmann ORCID logo d  and  Klavs F. Jensen ORCID logo *a  

* Corresponding authors

a Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
E-mail: kfjensen@mit.edu

b Department of Chemical Engineering, Inha University, 100 Inha-ro, Nam-gu, Incheon 22212, South Korea

c Department of Chemical and Biomolecular Engineering, North Carolina State University, 911 Partners Way, Raleigh, NC 27695, USA

d Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland

Abstract

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.

Graphical abstract: A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

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Article information

DOI
https://doi.org/10.1039/C7CC03584E
Article type
Communication
Submitted
08 May 2017
Accepted
25 May 2017
First published
25 May 2017

Chem. Commun., 2017,53, 6649-6652

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A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

Y. Hwang, C. W. Coley, M. Abolhasani, A. L. Marzinzik, G. Koch, C. Spanka, H. Lehmann and K. F. Jensen, Chem. Commun., 2017, 53, 6649 DOI: 10.1039/C7CC03584E

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