Issue 21, 2017

Surface induced dissociation as a tool to study membrane protein complexes

Abstract

Native ion mobility mass spectrometry (MS) and surface induced dissociation (SID) are applied to study the integral membrane protein complexes AmtB and AqpZ. Fragments produced from SID are consistent with the solved structures of these complexes. SID is, therefore, a promising tool for characterization of membrane protein complexes.

Graphical abstract: Surface induced dissociation as a tool to study membrane protein complexes

Supplementary files

Article information

Article type
Communication
Submitted
02 Dec 2016
Accepted
15 Feb 2017
First published
20 Feb 2017

Chem. Commun., 2017,53, 3106-3109

Surface induced dissociation as a tool to study membrane protein complexes

S. R. Harvey, Y. Liu, W. Liu, V. H. Wysocki and A. Laganowsky, Chem. Commun., 2017, 53, 3106 DOI: 10.1039/C6CC09606A

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