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Issue 1, 2017
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A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

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Abstract

A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.

Graphical abstract: A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

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Supplementary files

Article information


Submitted
07 Oct 2016
Accepted
01 Dec 2016
First published
01 Dec 2016

Chem. Commun., 2017,53, 134-137
Article type
Communication

A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

D. Montagner, B. Fresch, K. Browne, V. Gandin and A. Erxleben, Chem. Commun., 2017, 53, 134
DOI: 10.1039/C6CC08100B

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