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Issue 15, 2017
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First report on bio-catalytic N-formylation of amines using ethyl formate

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Abstract

A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also works on a large scale in high yield.

Graphical abstract: First report on bio-catalytic N-formylation of amines using ethyl formate

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Supplementary files

Article information


Submitted
21 Sep 2016
Accepted
25 Jan 2017
First published
30 Jan 2017

Chem. Commun., 2017,53, 2382-2385
Article type
Communication

First report on bio-catalytic N-formylation of amines using ethyl formate

R. E. Patre, S. Mal, P. R. Nilkanth, S. K. Ghorai, S. H. Deshpande, M. El Qacemi, T. Smejkal, S. Pal and B. N. Manjunath, Chem. Commun., 2017, 53, 2382
DOI: 10.1039/C6CC07679C

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