Issue 5, 2016

Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

Abstract

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(I)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier.

Graphical abstract: Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

Supplementary files

Article information

Article type
Edge Article
Submitted
28 Dec 2015
Accepted
09 Feb 2016
First published
09 Feb 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 3313-3316

Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

K. Xu, Y. Wang, V. Khakyzadeh and B. Breit, Chem. Sci., 2016, 7, 3313 DOI: 10.1039/C5SC04984A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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