Issue 98, 2016, Issue in Progress

One-pot synthesis of 2,4,6-triarylpyridines from β-nitrostyrenes, substituted salicylic aldehydes and ammonium acetate

Abstract

A protocol for the synthesis of 2,4,6-trisubstituted pyridines from the β-nitrostyrenes, available substituted salicylic aldehydes and ammonium acetate was developed. The present strategy features high chemoselectivity and excellent tolerance for a broad range of functional groups, in which the β-nitrostyrenes generated from aldehydes and nitromethane, substituted salicylic aldehydes and ammonium acetate were respectively employed as simple and easily available substrates. This efficient method provides fast access to a variety of structurally diverse pyridine derivatives. The structures of two typical products were confirmed by X-ray crystallography.

Graphical abstract: One-pot synthesis of 2,4,6-triarylpyridines from β-nitrostyrenes, substituted salicylic aldehydes and ammonium acetate

Supplementary files

Article information

Article type
Communication
Submitted
22 Jul 2016
Accepted
02 Oct 2016
First published
03 Oct 2016

RSC Adv., 2016,6, 95957-95964

One-pot synthesis of 2,4,6-triarylpyridines from β-nitrostyrenes, substituted salicylic aldehydes and ammonium acetate

X. Qing, T. Wang, F. Zhang and C. Wang, RSC Adv., 2016, 6, 95957 DOI: 10.1039/C6RA18630K

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