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Issue 73, 2016, Issue in Progress
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Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

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Abstract

A novel thermostable ω-transaminase from Thermomicrobium roseum which showed broad substrate specificity and high enantioselectivity was identified, expressed and biochemically characterized. The advantage of this enzyme to remove volatile inhibitory by-products was demonstrated by performing asymmetric synthesis and kinetic resolution at high temperature.

Graphical abstract: Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

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Publication details

The article was received on 10 Jun 2016, accepted on 13 Jul 2016 and first published on 13 Jul 2016


Article type: Communication
DOI: 10.1039/C6RA15110H
Citation: RSC Adv., 2016,6, 69257-69260

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    Identification of novel thermostable ω-transaminase and its application for enzymatic synthesis of chiral amines at high temperature

    S. Mathew, K. Deepankumar, G. Shin, E. Y. Hong, B. Kim, T. Chung and H. Yun, RSC Adv., 2016, 6, 69257
    DOI: 10.1039/C6RA15110H

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