Sc(OTf)3-catalyzed cyclization of α-allylated 1,3-dicarbonyls: an efficient access to 2,2-disubstituted 2,3-dihydrofuran derivatives

Ziping Cao; Rumeng Zhang; Xin Meng; Hui Li; Jie Li; Hongbo Zhu; Guang Chen; Xuejun Sun; Jinmao You

doi:10.1039/C6RA14051C

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Sc(OTf)₃-catalyzed cyclization of α-allylated 1,3-dicarbonyls: an efficient access to 2,2-disubstituted 2,3-dihydrofuran derivatives†

Ziping Cao,*^ab Rumeng Zhang,^a Xin Meng,^a Hui Li,^a Jie Li,^a Hongbo Zhu,^a Guang Chen,^ab Xuejun Sun^a and Jinmao You*^ab

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* Corresponding authors

^a School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, China
E-mail: caozp_qfnu@163.com, jmyou6304@163.com

^b Shandong Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, Qufu 273165, Shandong, China

Abstract

A method to prepare functionalized 2,3-dihydrofurans by Sc(OTf)₃-catalyzed cyclization of α-allylated 1,3-dicarbonyl compounds is reported. The reactions were shown to be operationally simplistic and proceed efficiently for a variety of substrates, leading to the formation of 2,2-disubstituted 2,3-dihydrofurans in good to excellent yields.

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Article information

DOI: https://doi.org/10.1039/C6RA14051C
Article type: Communication
Submitted: 30 May 2016
Accepted: 31 Jul 2016
First published: 01 Aug 2016

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RSC Adv., 2016,6, 74582-74585

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Sc(OTf)₃-catalyzed cyclization of α-allylated 1,3-dicarbonyls: an efficient access to 2,2-disubstituted 2,3-dihydrofuran derivatives

Z. Cao, R. Zhang, X. Meng, H. Li, J. Li, H. Zhu, G. Chen, X. Sun and J. You, RSC Adv., 2016, 6, 74582 DOI: 10.1039/C6RA14051C

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