Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 74, 2016
Previous Article Next Article

Small molecule therapeutic-loaded liposomes as therapeutic carriers: from development to clinical applications

Author affiliations

Abstract

While small hydrophilic therapeutic molecules have proved to be exceptionally effective in curing diseases, their in vivo efficacy remains low. Small molecule therapeutics infused in vivo result in uncontrolled bio-distribution that causes dilution and unwanted side effects. Therefore, global research to search for ideal carriers for small molecule therapeutics has gained attention seeking to increase efficiency of targeting desired cells. Liposomes are one class of nanocarriers that could encapsulate both hydrophilic and lipophilic small molecule therapeutics, protect them against physiological degradation and deliver them into targeted cells. In this review, studies done from the past up to the present are summarized, and various methods and mechanisms for encapsulation of small therapeutic molecules in liposomes for targeted delivery and triggered release, as well as their potential in the clinical uses, will be discussed.

Graphical abstract: Small molecule therapeutic-loaded liposomes as therapeutic carriers: from development to clinical applications

Back to tab navigation

Article information


Submitted
16 Apr 2016
Accepted
05 Jul 2016
First published
20 Jul 2016

RSC Adv., 2016,6, 70592-70615
Article type
Review Article

Small molecule therapeutic-loaded liposomes as therapeutic carriers: from development to clinical applications

J. Y. Hwang, Z. Li and X. J. Loh, RSC Adv., 2016, 6, 70592
DOI: 10.1039/C6RA09854A

Social activity

Search articles by author

Spotlight

Advertisements