Synthesis of multisubstituted furans via Cu(i)-catalyzed annulation of ketones with alkynoate under ligand- and additive-free conditions†
Abstract
A facile and efficient annulation strategy for the synthesis of multisubstituted furan derivatives has been achieved under mild conditions. The developed transformation via C(sp3)–H bond functionalization catalyzed by copper(I) salts using benzoyl peroxide as an external oxidant possess some obvious advantages. This ligand- and additive-free cyclization protocol offers an environmentally friendly and efficient access to biologically important scaffolds from readily available substrates.