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Issue 2, 2016
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Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids

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Abstract

A Pd-catalyzed arylation of lactic acid employing 8-aminoquinoline as the directing group has been reported. The protocol is found to be compatible with a broad range of synthetically useful functional groups, thus providing a practical route to chiral β-aryl-α-hydroxy acids. Further, the new reaction has also been applied to the synthesis of pharmaceutically important α-hydroxy acids, such as LY519818 and tesaglitazar.

Graphical abstract: Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids

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Supplementary files

Article information


Submitted
17 Oct 2015
Accepted
03 Dec 2015
First published
07 Dec 2015

Org. Chem. Front., 2016,3, 204-208
Article type
Research Article

Palladium-catalyzed C(sp3)–H arylation of lactic acid: efficient synthesis of chiral β-aryl-α-hydroxy acids

K. Chen, X. Li, S. Zhang and B. Shi, Org. Chem. Front., 2016, 3, 204
DOI: 10.1039/C5QO00319A

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