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Issue 37, 2016
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A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation

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Abstract

Although the biosynthetic pathway of Neocarazostatin A (1) has been identified, the detailed enzymatic reactions underlying the assembly of the carbazole ring still remain largely unknown. We demonstrate here that NzsH, a putative thiamine diphosphate dependent enzyme, can catalyze an acyloin coupling reaction between indole-3-pyruvate and pyruvate to generate a β-ketoacid intermediate. Our findings thus shed light on further characterization of the unusual biosynthetic pathway of the bacterial tricyclic carbazole alkaloids.

Graphical abstract: A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation

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Article information


Submitted
01 Aug 2016
Accepted
31 Aug 2016
First published
01 Sep 2016

This article is Open Access

Org. Biomol. Chem., 2016,14, 8679-8684
Article type
Communication

A ThDP-dependent enzymatic carboligation reaction involved in Neocarazostatin A tricyclic carbazole formation

L. Su, M. Lv, K. Kyeremeh, Z. Deng, H. Deng and Y. Yu, Org. Biomol. Chem., 2016, 14, 8679
DOI: 10.1039/C6OB01651K

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