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Issue 21, 2016
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Iridium(III)-catalyzed regioselective C7-sulfonamidation of indoles

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Iridium(III)-catalyzed direct C7-sulfonamidation of indoles with sulfonyl azides is described. The developed method has good compatibility with diverse functional groups, providing various 7-amino-substituted indoles with good to excellent yields in a short time under mild reaction conditions. The key feature of the developed method is the regioselective functionalization at the C7-position of 2,3-unsubstituted indoles. Biologically active compounds can be obtained using this protocol. The application of the iridium(III) catalyst and directing group plays a crucial role in the regioselectivity of the developed reaction.

Graphical abstract: Iridium(iii)-catalyzed regioselective C7-sulfonamidation of indoles

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The article was received on 29 Apr 2016, accepted on 09 May 2016 and first published on 09 May 2016

Article type: Communication
DOI: 10.1039/C6OB00926C
Citation: Org. Biomol. Chem., 2016,14, 4804-4808
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    Iridium(III)-catalyzed regioselective C7-sulfonamidation of indoles

    Z. Song and A. P. Antonchick, Org. Biomol. Chem., 2016, 14, 4804
    DOI: 10.1039/C6OB00926C

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