Issue 23, 2016
From the journal:

Organic & Biomolecular Chemistry

Fast regioselective sulfonylation of pyridine/quinoline N-oxides induced by iodine†

Ruijia Wang,ab   Zebing Zeng,*a   Chuang Chen,a   Niannian Yi,a   Jun Jiang,a   Zhong Cao,b   Wei Denga  and  Jiannan Xiang*a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P.R. China
E-mail: jnxiang@hun.edu.cn, zbzeng@hnu.edu.cn

b Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410004, P.R. China

Abstract

Fast sulfonylation of pyridine/quinoline N-oxides induced by iodine is demonstrated herein. The regioselective protocol occurs under metal-free conditions in a short reaction time (10 min), exhibiting high efficiency (up to 92% yield) and good compatibility (up to 33 examples). A gram-scale reaction was conducted with only a slight loss of production.

Graphical abstract: Fast regioselective sulfonylation of pyridine/quinoline N-oxides induced by iodine

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Article information

DOI
https://doi.org/10.1039/C6OB00925E
Article type
Paper
Submitted
29 Apr 2016
Accepted
16 May 2016
First published
17 May 2016

Org. Biomol. Chem., 2016,14, 5317-5321

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Fast regioselective sulfonylation of pyridine/quinoline N-oxides induced by iodine

R. Wang, Z. Zeng, C. Chen, N. Yi, J. Jiang, Z. Cao, W. Deng and J. Xiang, Org. Biomol. Chem., 2016, 14, 5317 DOI: 10.1039/C6OB00925E

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