Issue 14, 2016

Gold(iii)-catalyzed synthesis of aroylbenzo[b]oxepin-3-ones from ortho-O-propargyl-1-one substituted arylaldehydes

Abstract

An efficient gold-catalyzed intramolecular cyclization of ortho-O-propargyl-1-one substituted arylaldehydes has been achieved for the generation of substituted aroylbenzo[b]oxepin-3-one derivatives in moderate to good yields. This synthetic transformation proceeds via gold-catalysed oxidation of the internal alkyne moiety followed by an intramolecular condensation leading to seven-membered oxacycles.

Graphical abstract: Gold(iii)-catalyzed synthesis of aroylbenzo[b]oxepin-3-ones from ortho-O-propargyl-1-one substituted arylaldehydes

Supplementary files

Article information

Article type
Paper
Submitted
30 Dec 2015
Accepted
04 Mar 2016
First published
07 Mar 2016

Org. Biomol. Chem., 2016,14, 3526-3535

Gold(III)-catalyzed synthesis of aroylbenzo[b]oxepin-3-ones from ortho-O-propargyl-1-one substituted arylaldehydes

N. S. V. M. R. Mangina, S. Suresh, B. Sridhar and G. V. Karunakar, Org. Biomol. Chem., 2016, 14, 3526 DOI: 10.1039/C5OB02676H

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