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Issue 2, 2016
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A structural model for multimodular NRPS assembly lines

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Abstract

This viewpoint article focuses on the structures of the dissected catalytic domains of non-ribosomal peptide synthetases (NRPSs) associated with substrate selection and activation (A domain), substrate shuttling among the active sites (PCP domain), peptide bond formation (C domain) and product release (TE domain). Structural details of these essential components of the NRPS machinery, integrated in a didomain (PCP-C) and an elongation module (C-A-PCP), were used to generate a model for a multimodular NRPS assembly line.

Graphical abstract: A structural model for multimodular NRPS assembly lines

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Publication details

The article was received on 28 Jul 2015 and first published on 02 Oct 2015


Article type: Viewpoint
DOI: 10.1039/C5NP00082C
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Citation: Nat. Prod. Rep., 2016,33, 136-140
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    A structural model for multimodular NRPS assembly lines

    M. A. Marahiel, Nat. Prod. Rep., 2016, 33, 136
    DOI: 10.1039/C5NP00082C

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