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Issue 4, 2016
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Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

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Abstract

A cobaltoceniumethynyl gold(I) complex with a triphenylphosphane ligand triggered efficient cytotoxic effects in cancer cells in contrast to a derivative with two cobaltocenium moieties. The complex effectively inhibited the enzyme thioredoxin reductase (TrxR) suggesting this enzyme as a possible biological target. The cellular uptake of both metal fragments of the active complex was studied by atomic absorption spectroscopy and indicated a high biological stability of the complex.

Graphical abstract: Cobaltoceniumethynyl gold(i) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

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Publication details

The article was received on 08 Dec 2015, accepted on 21 Dec 2015 and first published on 23 Dec 2015


Article type: Communication
DOI: 10.1039/C5DT04796J
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Dalton Trans., 2016,45, 1345-1348
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    Cobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes

    S. Vanicek, H. Kopacka, K. Wurst, S. Vergeiner, S. Kankowski, J. Schur, B. Bildstein and I. Ott, Dalton Trans., 2016, 45, 1345
    DOI: 10.1039/C5DT04796J

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