Issue 4, 2016
From the journal:

Dalton Transactions

Synthesis, cytotoxicity and anti-cancer activity of new alkynyl-gold(i) complexes†

Assunta De Nisi,a   Christian Bergamini,b   Marco Leonzio,a   Giorgio Sartor,b   Romana Fato,b   Marina Naldi,b   Magda Monari,*a   Natalia Calonghi*b  and  Marco Bandini*a  

* Corresponding authors

a Department of Chemistry “G. Ciamician”, Alma Mater Studiorum – University of Bologna, Via Selmi 2, 40126 Bologna, Italy
E-mail: marco.bandini@unibo.it
Fax: +39-051-2099456

b Department of Pharmacy and Biotechnology, Alma Mater Studiorum – University of Bologna, Via Irnerio 48, 40126 Bologna, Italy

Abstract

Alkynyl(triphenylphosphine)gold(I) complexes carrying variously substituted propargylic amines have been synthesized and fully characterized in solution and solid state. High levels of toxicity (i.e. micromolar range) were recognized for a series of cancer cell lines with particular emphasis on HT29, IGROV1, HL60 and I407. In particular the lead compound 3ab was identified as the most active compound in all cell lines (IC50: 1.7–7.9 μM).

Graphical abstract: Synthesis, cytotoxicity and anti-cancer activity of new alkynyl-gold(i) complexes

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Article information

DOI
https://doi.org/10.1039/C5DT02905H
Article type
Paper
Submitted
28 Jul 2015
Accepted
08 Dec 2015
First published
21 Dec 2015

Dalton Trans., 2016,45, 1546-1553

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Synthesis, cytotoxicity and anti-cancer activity of new alkynyl-gold(I) complexes

A. De Nisi, C. Bergamini, M. Leonzio, G. Sartor, R. Fato, M. Naldi, M. Monari, N. Calonghi and M. Bandini, Dalton Trans., 2016, 45, 1546 DOI: 10.1039/C5DT02905H

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