Issue 81, 2016
From the journal:

Chemical Communications

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation†

Hyoung Eun Bae,a   Jonas S. Mortensen,b   Orquidea Ribeiro,c   Yang Du,d   Muhammad Ehsan,a   Brian K. Kobilka,d   Claus J. Loland,b   Bernadette Byrnec  and  Pil Seok Chae*a  

* Corresponding authors

a Department of Bionanotechnology, Hanyang University, Ansan, Korea
E-mail: pchae@hanyang.ac.kr

b Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200 Copenhagen, Denmark
E-mail: cllo@sund.ku.dk

c Department of Life Sciences, Imperial College London, London, UK
E-mail: b.byrne@imperial.ac.uk

d Molecular and Cellular Physiology, Stanford, CA 94305, USA
E-mail: kobilka@stanford.edu

Abstract

A novel class of detergents, designated tandem neopentyl glycol maltosides (TNMs), were evaluated with four target membrane proteins. The best detergent varied depending on the target, but TNM-C12L and TNM-C11S were notable for their ability to confer increased membrane protein stability compared to DDM. These agents have potential for use in membrane protein research.

Graphical abstract: Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC06147H
Article type
Communication
Submitted
26 Jul 2016
Accepted
13 Sep 2016
First published
13 Sep 2016

Chem. Commun., 2016,52, 12104-12107

Permissions

Request permissions

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation

H. E. Bae, J. S. Mortensen, O. Ribeiro, Y. Du, M. Ehsan, B. K. Kobilka, C. J. Loland, B. Byrne and P. S. Chae, Chem. Commun., 2016, 52, 12104 DOI: 10.1039/C6CC06147H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements