Direct visualization of sub-femtomolar circulating microRNAs in serum based on the duplex-specific nuclease-amplified oriented assembly of gold nanoparticle dimers

Longhua Guo; Yi Lin; Chen Chen; Bin Qiu; Zhenyu Lin; Guonan Chen

doi:10.1039/C6CC06021H

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Direct visualization of sub-femtomolar circulating microRNAs in serum based on the duplex-specific nuclease-amplified oriented assembly of gold nanoparticle dimers†

Longhua Guo,

*^a Yi Lin,^a Chen Chen,^a Bin Qiu,^a Zhenyu Lin*^a and Guonan Chen^a

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* Corresponding authors

^a Institute of Nanomedicine and Nanobiosensing, The Key Lab of Analysis and Detection Technology for Food Safety of the MOE and Fujian Province, College of Chemistry, Fuzhou University, Fuzhou, China
E-mail: guolh@fzu.edu.cn, zylin@fzu.edu.cn

Abstract

Direct visual detection of circulating microRNAs could be a big challenge due to the ultralow concentration of microRNAs in real samples. Herein, we combine the techniques of nuclease amplification and oriented assembly of gold nanoparticle dimers to realize visual detection of microRNAs in human serum with the naked eye.

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Article information

DOI: https://doi.org/10.1039/C6CC06021H
Article type: Communication
Submitted: 21 Jul 2016
Accepted: 17 Aug 2016
First published: 19 Aug 2016

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Chem. Commun., 2016,52, 11347-11350

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Direct visualization of sub-femtomolar circulating microRNAs in serum based on the duplex-specific nuclease-amplified oriented assembly of gold nanoparticle dimers

L. Guo, Y. Lin, C. Chen, B. Qiu, Z. Lin and G. Chen, Chem. Commun., 2016, 52, 11347 DOI: 10.1039/C6CC06021H

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Chemical Communications

Direct visualization of sub-femtomolar circulating microRNAs in serum based on the duplex-specific nuclease-amplified oriented assembly of gold nanoparticle dimers†

Abstract

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Direct visualization of sub-femtomolar circulating microRNAs in serum based on the duplex-specific nuclease-amplified oriented assembly of gold nanoparticle dimers

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