Issue 73, 2016
From the journal:

Chemical Communications

An intracellular anchor regulates the distribution of bioactive molecules†

Jianwu Wang,ab   Shengliang Li,a   Hui Chen,a   Rong Hu,a   Meng Li,a   Fengting Lv,a   Libing Liu,a   Yuguo Ma*b  and  Shu Wang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, P. R. China
E-mail: wangshu@iccas.ac.cn

b Beijing National Laboratory for Molecular Sciences, College of Chemistry, Peking University, Beijing 100871, P. R. China
E-mail: ygma@pku.edu.cn

Abstract

Based on bioorthogonal tetrazine ligation, a pre-targeted anchor strategy was developed to regulate the intracellular distribution of bioactive molecules. This strategy could solve the issue regarding the permeability and targeting ability of bioactive molecules in the specific organelles of living cells.

Graphical abstract: An intracellular anchor regulates the distribution of bioactive molecules

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Article information

DOI
https://doi.org/10.1039/C6CC05385H
Article type
Communication
Submitted
28 Jun 2016
Accepted
04 Aug 2016
First published
04 Aug 2016

Chem. Commun., 2016,52, 11004-11007

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An intracellular anchor regulates the distribution of bioactive molecules

J. Wang, S. Li, H. Chen, R. Hu, M. Li, F. Lv, L. Liu, Y. Ma and S. Wang, Chem. Commun., 2016, 52, 11004 DOI: 10.1039/C6CC05385H

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