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Issue 64, 2016
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Fluorescent vinblastine probes for live cell imaging

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Abstract

Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.

Graphical abstract: Fluorescent vinblastine probes for live cell imaging

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Publication details

The article was received on 16 May 2016, accepted on 14 Jul 2016 and first published on 14 Jul 2016


Article type: Communication
DOI: 10.1039/C6CC04129A
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Chem. Commun., 2016,52, 9953-9956

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    Fluorescent vinblastine probes for live cell imaging

    L. G. Meimetis, R. J. Giedt, H. Mikula, J. C. Carlson, R. H. Kohler, D. B. Pirovich and R. Weissleder, Chem. Commun., 2016, 52, 9953
    DOI: 10.1039/C6CC04129A

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