Issue 57, 2016

Photosensitizer anchored gold nanorods for targeted combinational photothermal and photodynamic therapy

Abstract

Silylated zinc phthalocyanine (ZnPc) was anchored onto silica-coated gold nanorods (AuNR) with retained local surface plasmon resonance (LSPR). Independent LSPR and singlet oxygen production of anchored ZnPc enhance the photothermal and photodynamic efficacy of the obtained AuNR-Si-ZnPc under NIR light excitation. AuNR-Si-ZnPc was further grafted with hyaluronic acid (HA). Since HA has selective targeting capability to CD44 antigens, the final hybrid could target cancer cells directly for synergistic photothermal and photodynamic therapy.

Graphical abstract: Photosensitizer anchored gold nanorods for targeted combinational photothermal and photodynamic therapy

Supplementary files

Article information

Article type
Communication
Submitted
13 Apr 2016
Accepted
15 Jun 2016
First published
15 Jun 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2016,52, 8854-8857

Photosensitizer anchored gold nanorods for targeted combinational photothermal and photodynamic therapy

H. P. Tham, H. Chen, Y. H. Tan, Q. Qu, S. Sreejith, L. Zhao, S. S. Venkatraman and Y. Zhao, Chem. Commun., 2016, 52, 8854 DOI: 10.1039/C6CC03076A

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