Issue 18, 2016

Visible light-induced intramolecular dearomative cyclization of α-bromo-N-benzyl-alkylamides: efficient construction of 2-azaspiro[4.5]decanes

Abstract

An efficient intramolecular dearomative cyclization via visible light-induced photoredox catalysis allows for a highly regioselective dearomative cyclization of α-bromo-N-benzyl-alkylamides to construct 2-azaspiro[4.5]decanes in the presence of an iridium catalyst.

Graphical abstract: Visible light-induced intramolecular dearomative cyclization of α-bromo-N-benzyl-alkylamides: efficient construction of 2-azaspiro[4.5]decanes

Supplementary files

Article information

Article type
Communication
Submitted
25 Nov 2015
Accepted
26 Jan 2016
First published
01 Feb 2016

Chem. Commun., 2016,52, 3709-3712

Author version available

Visible light-induced intramolecular dearomative cyclization of α-bromo-N-benzyl-alkylamides: efficient construction of 2-azaspiro[4.5]decanes

B. Hu, Y. Li, W. Dong, K. Ren, X. Xie, J. Wan and Z. Zhang, Chem. Commun., 2016, 52, 3709 DOI: 10.1039/C5CC09726F

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