Issue 7, 2016
From the journal:

Chemical Communications

Tumor cell-specific split aptamers: target-driven and temperature-controlled self-assembly on the living cell surface†

Jinlu Tang,‡a   Hui Shi,‡a   Xiaoxiao He,a   Yanli Lei,a   Qiuping Guo,a   Kemin Wang,*a   Lv'an Yana  and  Dinggeng Hea  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, China
E-mail: kmwang@hnu.edu.cn

Abstract

An activatable split aptamer probe with target-induced shape change and thermosensitivity was developed. Triggered by proteins on the cell surface, the probe could assemble into a desired binding shape, thus affording a FRET-based tumor cell assay. Moreover, a reversible cell catch/release strategy was realized through mild temperature switching (4 °C/37 °C).

Graphical abstract: Tumor cell-specific split aptamers: target-driven and temperature-controlled self-assembly on the living cell surface

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Article information

DOI
https://doi.org/10.1039/C5CC08977H
Article type
Communication
Submitted
29 Oct 2015
Accepted
26 Nov 2015
First published
27 Nov 2015

Chem. Commun., 2016,52, 1482-1485

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Tumor cell-specific split aptamers: target-driven and temperature-controlled self-assembly on the living cell surface

J. Tang, H. Shi, X. He, Y. Lei, Q. Guo, K. Wang, L. Yan and D. He, Chem. Commun., 2016, 52, 1482 DOI: 10.1039/C5CC08977H

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