Azeotropic drying free [18F]FDG synthesis and its application to a lab-on-chip platform

S. Lindner; C. Rensch; S. Neubaur; M. Neumeier; R. Salvamoser; V. Samper; P. Bartenstein

doi:10.1039/C5CC07106B

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Azeotropic drying free [¹⁸F]FDG synthesis and its application to a lab-on-chip platform†

S. Lindner,*^a C. Rensch,^b S. Neubaur,^a M. Neumeier,^a R. Salvamoser,^b V. Samper^b and P. Bartenstein^a

Author affiliations

* Corresponding authors

^a Department of Nuclear Medicine, University Hospital Munich LMU, Marchioninistr. 15, 81377 Munich, Germany
E-mail: simon.lindner@med.uni-muenchen.de

^b GE Global Research, Freisinger Landstr. 50, 85748 Garching, Germany

Abstract

A very simple and time-saving cartridge-based drying technique for [¹⁸F]fluoride allows for an efficient [¹⁸F]FDG synthesis using protic solvents and high water content. This novel method has been adapted to a lab-on-chip synthesis platform mitigating the standard azeotropic drying process and demonstrating a proof of concept towards reduced hardware complexity for such systems.

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Article information

DOI: https://doi.org/10.1039/C5CC07106B
Article type: Communication
Submitted: 24 Aug 2015
Accepted: 09 Nov 2015
First published: 09 Nov 2015

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Chem. Commun., 2016,52, 729-732

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Azeotropic drying free [¹⁸F]FDG synthesis and its application to a lab-on-chip platform

S. Lindner, C. Rensch, S. Neubaur, M. Neumeier, R. Salvamoser, V. Samper and P. Bartenstein, Chem. Commun., 2016, 52, 729 DOI: 10.1039/C5CC07106B

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