Issue 6, 2016
From the journal:

Biomaterials Science

Fc-fusion mimetics†

H. Khalili,*ab   P. T. Khawb  and  S. Brocchini*ab  

* Corresponding authors

a UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK
E-mail: h.khalil@uel.ac.uk, steve.brocchini@ucl.ac.uk

b NIHR Biomedical Research Centre, Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK

Abstract

The Fc-fusion mimetic RpR [2 with combining low line] was prepared by disulfide bridging conjugation using PEG in the place of the Fc. RpR [2 with combining low line] displayed higher affinity for VEGF than aflibercept. This is caused primarily by a slower dissociation rate, which can prolong a drug at its site of action. RpRs have considerable potential for development as stable, organ specific therapeutics.

Graphical abstract: Fc-fusion mimetics

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6BM00077K
Article type
Communication
Submitted
02 Feb 2016
Accepted
08 Apr 2016
First published
29 Apr 2016

Biomater. Sci., 2016,4, 943-947

Author version available

Download author version (PDF)

Permissions

Request permissions

Fc-fusion mimetics

H. Khalili, P. T. Khaw and S. Brocchini, Biomater. Sci., 2016, 4, 943 DOI: 10.1039/C6BM00077K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements