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Issue 47, 2015
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A vegetable oil-based organogel for use in pH-mediated drug delivery

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Abstract

Organogels prepared with vegetable oils as the liquid organic phase present an excellent platform for the controlled delivery of hydrophobic guest molecules. We disclose a graft copolymer comprised of a poly(L-serine) backbone linked to alkane side-chains by hydrolytically susceptible ester bonds, that is capable of gelating edible safflower oil. The thermoresponsive organogel formed, which is non-cytotoxic, is capable of withholding guest molecules before undergoing targeted disassembly upon incubation in solutions of acidic pH, permitting the directed release of payload molecules. The presented material offers an extremely promising candidate for the controlled delivery of hydrophobic agents within acidic environments, such as cancer tumour sites.

Graphical abstract: A vegetable oil-based organogel for use in pH-mediated drug delivery

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Supplementary files

Article information


Submitted
28 Aug 2015
Accepted
18 Sep 2015
First published
18 Sep 2015

Soft Matter, 2015,11, 9160-9167
Article type
Paper
Author version available

A vegetable oil-based organogel for use in pH-mediated drug delivery

M. Khuphe, B. Mukonoweshuro, A. Kazlauciunas and P. D. Thornton, Soft Matter, 2015, 11, 9160
DOI: 10.1039/C5SM02176F

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