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Issue 121, 2015
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Hydrothermal synthesis of defective TiO2 nanoparticles for long-wavelength visible light-photocatalytic killing of cancer cells

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Abstract

Defective TiO2 nanoparticles (d-TiO2 NPs) were successfully synthesized using a simple hydrothermal technique through the formation of liposome–TiO2 composites using P25 TiO2 powder as the starting material. The morphology and vibrational structures of the d-TiO2 NPs were characterized by various techniques, including X-ray diffraction, transmission electron microscopy, and Fourier transform-infrared and Raman spectroscopic analyses. The synthesized d-TiO2 NPs were composed of both the rutile and anatase phases of TiO2 with a diameter of approximately 25 nm, and they exhibited absorption of broad visible light including near-infrared wavelengths, from 400 nm to 1000 nm, which was confirmed by diffuse reflectance spectroscopy and X-ray photoelectron spectroscopy. The agglomeration size of the d-TiO2 NPs in aqueous solution was lesser (224 nm) than that of P25 TiO2 (1440 nm). Therefore, the synthesized d-TiO2 NPs could more easily infiltrate the membrane and cytoplasm of cancer cells via endocytosis than could P25 TiO2. Consequently, upon irradiation with long-wavelength visible light (400–800 nm), the d-TiO2 NPs could generate reactive oxygen species, including singlet oxygen, leading to the destruction of cancer cells. These results suggest that the newly fabricated d-TiO2 NPs are promising nanomaterials for future in vivo photodynamic therapy of cancer.

Graphical abstract: Hydrothermal synthesis of defective TiO2 nanoparticles for long-wavelength visible light-photocatalytic killing of cancer cells

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Publication details

The article was received on 16 Sep 2015, accepted on 12 Nov 2015 and first published on 23 Nov 2015


Article type: Paper
DOI: 10.1039/C5RA19045B
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Citation: RSC Adv., 2015,5, 99789-99796
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    Hydrothermal synthesis of defective TiO2 nanoparticles for long-wavelength visible light-photocatalytic killing of cancer cells

    J. Lee, Y. H. Lee, J. S. Choi, K. S. Park, K. S. Chang and M. Yoon, RSC Adv., 2015, 5, 99789
    DOI: 10.1039/C5RA19045B

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