Issue 64, 2015
From the journal:

RSC Advances

Friedel–Crafts alkylation of indoles in deep eutectic solvent†

Atul Kumar,*ab   Ratnakar Dutt Shukla,a   Dhiraj Yadavc  and  Lalit Prakash Guptaa  

* Corresponding authors

a Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute (CDRI), Lucknow, India
E-mail: dratulsax@gmail.com, atul_kumar@cdri.res.in
Fax: +91-522-26-234051
Tel: +91-522-26-12411

b Academy of Scientific & Innovative Research (AcSIR), New Delhi, India

c National Institute of Pharmaceutical Education and Research, ITI Campus, Raebareli, U.P., India

Abstract

The application of Deep Eutectic Solvent (DES) as a solvent and a working catalyst for Friedel–Crafts alkylation of indoles with isatin as well as homocyclic carbonyl compounds has been developed. The salient features of the present protocol are practical simplicity, excellent yields, product selectivity and reusability of reaction media.

Graphical abstract: Friedel–Crafts alkylation of indoles in deep eutectic solvent

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5RA08038J
Article type
Communication
Submitted
01 May 2015
Accepted
28 May 2015
First published
28 May 2015

RSC Adv., 2015,5, 52062-52065

Author version available

Download author version (PDF)

Permissions

Request permissions

Friedel–Crafts alkylation of indoles in deep eutectic solvent

A. Kumar, R. D. Shukla, D. Yadav and L. P. Gupta, RSC Adv., 2015, 5, 52062 DOI: 10.1039/C5RA08038J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements