Jump to main content
Jump to site search

Issue 34, 2015
Previous Article Next Article

Sequential one-pot approach for the synthesis of functionalized phthalans via Heck-reduction–cyclization (HRC) reactions

Author affiliations

Abstract

An efficient and practical method is described for the direct synthesis of 1,3-dihydroisobenzofurans, an important structural motif present in biologically active natural or synthetic compounds. The reaction was performed in an almost one-pot fashion via controlled [Pd]-catalyzed intermolecular Mizoroki–Heck coupling between 2-bromobenzaldehydes and allylic alcohols followed by reduction and treatment of crude diol with a Lewis acid to give 1,3-dihydroisobenzofurans. Significantly, the method enabled the synthesis of 1,3-dihydroisobenzofurans with simple to dense functionalities on the aromatic rings.

Graphical abstract: Sequential one-pot approach for the synthesis of functionalized phthalans via Heck-reduction–cyclization (HRC) reactions

Back to tab navigation

Supplementary files

Article information


Submitted
16 Jan 2015
Accepted
25 Feb 2015
First published
26 Feb 2015

RSC Adv., 2015,5, 26749-26761
Article type
Paper
Author version available

Sequential one-pot approach for the synthesis of functionalized phthalans via Heck-reduction–cyclization (HRC) reactions

J. Krishna, P. Niharika and G. Satyanarayana, RSC Adv., 2015, 5, 26749
DOI: 10.1039/C5RA00955C

Social activity

Search articles by author

Spotlight

Advertisements