Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 16, 2015
Previous Article Next Article

An “all-water” strategy for regiocontrolled synthesis of 2-aryl quinoxalines

Author affiliations

Abstract

A new synthetic strategy of tandem N-aroylmethylation-nitro reduction–cyclocondensation has been developed for the first and generalized regioselective synthesis of 2-aryl quinoxalines adopting “all water chemistry.” Water plays the critical role through hydrogen bond driven ‘synergistic electrophile–nucleophile dual activation’ for chemoselective N-aroylmethylation of o-nitroanilines, that underlines the origin of the regioselectivity, as the use of organic solvents proved to be ineffective. Water also provides beneficial effects during the nitro reduction and the penultimate cyclocondensation steps.

Graphical abstract: An “all-water” strategy for regiocontrolled synthesis of 2-aryl quinoxalines

Back to tab navigation

Supplementary files

Article information


Submitted
17 Dec 2014
Accepted
09 Jan 2015
First published
09 Jan 2015

RSC Adv., 2015,5, 11873-11883
Article type
Paper
Author version available

An “all-water” strategy for regiocontrolled synthesis of 2-aryl quinoxalines

B. Tanwar, P. Purohit, B. N. Raju, D. Kumar, D. N. Kommi and A. K. Chakraborti, RSC Adv., 2015, 5, 11873
DOI: 10.1039/C4RA16568C

Social activity

Search articles by author

Spotlight

Advertisements