Issue 12, 2015
From the journal:

Organic Chemistry Frontiers

Copper-catalyzed oxidative coupling reaction of α,β-unsaturated aldehydes with amidines: synthesis of 1,2,4-trisubstituted-1H-imidazole-5-carbaldehydes†

Yaxuan Li,ab   Yajie Fu,ab   Chaojie Ren,ab   Dong Tang,ab   Ping Wu,ab   Xu Mengc  and  Baohua Chen*ab  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, P. R. China

b Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou, P. R. China
E-mail: chbh@lzu.edu.cn
Fax: +86(931)8912582

c State Key Laboratory of Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P. R. China

Abstract

A practical and highly functional group-compatible synthesis of 1,2,4-trisubstituted-1H-imidazole-5-carbaldehydes has been developed via copper-catalyzed oxidative coupling of amidines and α,β-unsaturated aldehydes, which features aldehyde preservation, cheap catalysts, as well as high atom economy and mild conditions.

Graphical abstract: Copper-catalyzed oxidative coupling reaction of α,β-unsaturated aldehydes with amidines: synthesis of 1,2,4-trisubstituted-1H-imidazole-5-carbaldehydes

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Article information

DOI
https://doi.org/10.1039/C5QO00285K
Article type
Research Article
Submitted
15 Sep 2015
Accepted
03 Nov 2015
First published
04 Nov 2015

Org. Chem. Front., 2015,2, 1632-1636

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Copper-catalyzed oxidative coupling reaction of α,β-unsaturated aldehydes with amidines: synthesis of 1,2,4-trisubstituted-1H-imidazole-5-carbaldehydes

Y. Li, Y. Fu, C. Ren, D. Tang, P. Wu, X. Meng and B. Chen, Org. Chem. Front., 2015, 2, 1632 DOI: 10.1039/C5QO00285K

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