Issue 2, 2015

Copper(ii)-catalyzed methoxylation of unactivated (hetero)aryl C–H bonds using a removable bidentate auxiliary

Abstract

A copper(II)-catalyzed methoxylation of unactivated (hetero)aryl C–H bonds directed by our newly developed PIP directing group with methanol has been achieved. This protocol occurs efficiently with a catalytic amount of copper (5 mol%), is a simple and environmentally benign reaction system, has a broad substrate scope and high functional group tolerance.

Graphical abstract: Copper(ii)-catalyzed methoxylation of unactivated (hetero)aryl C–H bonds using a removable bidentate auxiliary

Supplementary files

Article information

Article type
Research Article
Submitted
24 Oct 2014
Accepted
15 Dec 2014
First published
17 Dec 2014

Org. Chem. Front., 2015,2, 119-123

Copper(II)-catalyzed methoxylation of unactivated (hetero)aryl C–H bonds using a removable bidentate auxiliary

X. Yin, Y. Li, J. Yuan, W. Gu and B. Shi, Org. Chem. Front., 2015, 2, 119 DOI: 10.1039/C4QO00276H

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