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Issue 45, 2015
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Total synthesis of calothrixin B via sequential Sonogashira coupling/copper-catalyzed oxidative cyclization

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Abstract

A total synthesis of the antimalarial indolo[3,2-j]phenanthridine alkaloid calothrixin B is reported. The key intermediate, ketoester 11, was assembled using sequential Sonogashira coupling and intra/intermolecular fashioned copper-catalyzed oxidative cyclization reactions.

Graphical abstract: Total synthesis of calothrixin B via sequential Sonogashira coupling/copper-catalyzed oxidative cyclization

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Article information


Submitted
23 Aug 2015
Accepted
11 Sep 2015
First published
11 Sep 2015

Org. Biomol. Chem., 2015,13, 11046-11051
Article type
Paper
Author version available

Total synthesis of calothrixin B via sequential Sonogashira coupling/copper-catalyzed oxidative cyclization

N. Ramkumar and R. Nagarajan, Org. Biomol. Chem., 2015, 13, 11046
DOI: 10.1039/C5OB01766A

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