Issue 27, 2015
From the journal:

Organic & Biomolecular Chemistry

Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling†

Xiang Sun,a   Xiao-Hui Lv,a   Lin-Miao Ye,a   Yu Hu,a   Yan-Yan Chen,a   Xue-Jing Zhanga  and  Ming Yan*a  

* Corresponding authors

a Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
E-mail: yanming@mail.sysu.edu.cn
Fax: +86-20-39943049
Tel: +86-20-39943049

Abstract

Iridium-catalyzed acceptorless dehydrogenative coupling of tertiary amines and arylamines has been developed. A number of benzimidazoles were prepared in good yields. An iridium-mediated C–H activation mechanism is suggested. This finding represents a novel strategy for the synthesis of benzimidazoles.

Graphical abstract: Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling

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Article information

DOI
https://doi.org/10.1039/C5OB00904A
Article type
Communication
Submitted
05 May 2015
Accepted
28 May 2015
First published
28 May 2015

Org. Biomol. Chem., 2015,13, 7381-7383

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Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling

X. Sun, X. Lv, L. Ye, Y. Hu, Y. Chen, X. Zhang and M. Yan, Org. Biomol. Chem., 2015, 13, 7381 DOI: 10.1039/C5OB00904A

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