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Issue 27, 2015
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Fluorinated enol ethers: their synthesis and reactivity

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Thanks to the beneficial effect of fluorine substitution on the pharmacokinetic properties of molecules, an ever increasing number of marketed drugs incorporate a fluorine atom into their structure. As a consequence, the synthesis of fluorinated molecules has become a very active research field. Among the numerous approaches, fluorinated enol ethers are valuable building blocks that allow the introduction of a fluoro- or difluoromethyl group through a wide variety of reactions. The present review lists different methods for their preparation and sums up their numerous synthetic applications.

Graphical abstract: Fluorinated enol ethers: their synthesis and reactivity

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The article was received on 28 Apr 2015, accepted on 28 May 2015 and first published on 28 May 2015

Article type: Review Article
DOI: 10.1039/C5OB00855G
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Citation: Org. Biomol. Chem., 2015,13, 7351-7380
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    Fluorinated enol ethers: their synthesis and reactivity

    M. Decostanzi, J.-M. Campagne and E. Leclerc, Org. Biomol. Chem., 2015, 13, 7351
    DOI: 10.1039/C5OB00855G

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