Issue 22, 2015

Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

Abstract

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)–H functionalization for the formation of C–O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.

Graphical abstract: Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

Supplementary files

Article information

Article type
Communication
Submitted
24 Mar 2015
Accepted
20 Apr 2015
First published
20 Apr 2015

Org. Biomol. Chem., 2015,13, 6158-6161

Author version available

Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

W. Xu, Q. Li, C. Cao, F. Zhang and H. Zheng, Org. Biomol. Chem., 2015, 13, 6158 DOI: 10.1039/C5OB00577A

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