Issue 13, 2015
From the journal:

Organic & Biomolecular Chemistry

Development of a flow method for the hydroboration/oxidation of olefins†

José A. Souto,*ab   Robert A. Stockmanc  and  Steven V. Leya  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
E-mail: svl1000@cam.ac.uk

b Departamento de Química Orgánica, Universidade de Vigo, Vigo, Spain
E-mail: souto@uvigo.es

c School of Chemistry, University of Nottingham, Nottingham, UK
E-mail: robert.stockman@nottingham.ac.uk

Abstract

A method for the continuous preparation of alcohols by hydroboration/oxidation of olefins using flow techniques is described. The process allows the isolation of up to 120 mmol h−1 of the desired alcohol in a very rapid manner with good functional group tolerance. The flow setup can be modified to perform a continuous extraction of the desired alcohol from the biphasic mixture produced by the reaction.

Graphical abstract: Development of a flow method for the hydroboration/oxidation of olefins

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Article information

DOI
https://doi.org/10.1039/C5OB00170F
Article type
Communication
Submitted
28 Jan 2015
Accepted
12 Feb 2015
First published
17 Feb 2015
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 3871-3877

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Development of a flow method for the hydroboration/oxidation of olefins

J. A. Souto, R. A. Stockman and S. V. Ley, Org. Biomol. Chem., 2015, 13, 3871 DOI: 10.1039/C5OB00170F

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