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Issue 11, 2015
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A new method for the synthesis of difluoromethyl enol ethers by O-difluoromethylation of 1,3-diones with ClCF2CO2Et

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Abstract

A facile, efficient, single-step protocol for the synthesis of difluoromethyl enol ether derivatives by O-difluoromethylation of 1,3-diones via in situ generation of difluorocarbene from ClCF2CO2Et has been developed. The functional group tolerance, scalability of the reaction, and mild reaction conditions make it an attractive protocol for the synthesis of biologically relevant difluoromethyl ethers of interest to the pharmaceutical and agrochemical industries.

Graphical abstract: A new method for the synthesis of difluoromethyl enol ethers by O-difluoromethylation of 1,3-diones with ClCF2CO2Et

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Publication details

The article was received on 06 Jan 2015, accepted on 27 Jan 2015 and first published on 27 Jan 2015


Article type: Paper
DOI: 10.1039/C5OB00020C
Org. Biomol. Chem., 2015,13, 3432-3437

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    A new method for the synthesis of difluoromethyl enol ethers by O-difluoromethylation of 1,3-diones with ClCF2CO2Et

    X. Lin and Z. Weng, Org. Biomol. Chem., 2015, 13, 3432
    DOI: 10.1039/C5OB00020C

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