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Issue 4, 2015
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Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones

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Abstract

In this paper, a simple and highly efficient ruthenium-catalyzed direct C3 alkylation of indoles with various α,β-unsaturated ketones without chelation assistance has been developed. This novel C–H activation methodology exhibits a broad substrate scope such as different substituted indoles, pyrroles, and other azoles. Further synthetic applications of the alkylation products can lead to more attractive 3,4-fused tricyclic indoles.

Graphical abstract: Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones

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Publication details

The article was received on 05 Oct 2014, accepted on 13 Nov 2014 and first published on 14 Nov 2014


Article type: Paper
DOI: 10.1039/C4OB02124J
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Org. Biomol. Chem., 2015,13, 1254-1263

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    Ruthenium-catalyzed direct C3 alkylation of indoles with α,β-unsaturated ketones

    S. Li, H. Lin, X. Zhang and L. Dong, Org. Biomol. Chem., 2015, 13, 1254
    DOI: 10.1039/C4OB02124J

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