Jump to main content
Jump to site search

Issue 8, 2015
Previous Article Next Article

Interaction of mercury and selenium in the larval stage zebrafish vertebrate model

Author affiliations

Abstract

The compounds of mercury can be more toxic than those of any other non-radioactive heavy element. Despite this, environmental mercury pollution and human exposure to mercury are widespread, and are increasing. While the unusual ability of selenium to cancel the toxicity of mercury compounds has been known for nearly five decades, only recently have some aspects of the molecular mechanisms begun to be understood. We report herein a study of the interaction of mercury and selenium in the larval stage zebrafish, a model vertebrate system, using X-ray fluorescence imaging. Exposure of larval zebrafish to inorganic mercury shows nano-scale structures containing co-localized mercury and selenium. No such co-localization is seen with methylmercury exposure under similar conditions. Micro X-ray absorption spectra support the hypothesis that the co-localized deposits are most likely comprised of highly insoluble mixed chalcogenide HgSxSe(1−x) where x is 0.4–0.9, probably with the cubic zincblende structure.

Graphical abstract: Interaction of mercury and selenium in the larval stage zebrafish vertebrate model

Back to tab navigation

Publication details

The article was received on 02 Jun 2015, accepted on 30 Jun 2015 and first published on 01 Jul 2015


Article type: Paper
DOI: 10.1039/C5MT00145E
Author version
available:
Download author version (PDF)
Metallomics, 2015,7, 1247-1255

  •   Request permissions

    Interaction of mercury and selenium in the larval stage zebrafish vertebrate model

    T. C. MacDonald, M. Korbas, A. K. James, N. J. Sylvain, M. J. Hackett, S. Nehzati, P. H. Krone, G. N. George and I. J. Pickering, Metallomics, 2015, 7, 1247
    DOI: 10.1039/C5MT00145E

Search articles by author

Spotlight

Advertisements