An interpenetrated bioactive nonlinear optical MOF containing a coordinated quinolone-like drug and Zn(ii) for pH-responsive release

Abstract

A new interpenetrated bioactive nonlinear optical metal–organic framework [Zn₂(ppa)₂(1,3-bdc)(H₂O)] has been designed and synthesized, which shows both a high drug content of 63.9% and a good slow release effect in simulated physical conditions compared to other non-interpenetrated bioactive MOFs. It also shows a large powder second-harmonic generation (SHG) efficiency of 5.6 times that of KH₂PO₄ (particle size: 150–200 μm).