Iron-catalyzed aerobic oxidative functionalization of sp3 C–H bonds: a versatile strategy for the construction of N-heterocycles

Abstract

Iron-catalyzed aerobic oxidative functionalization of sp³ C–H bonds has been developed for the construction of N-heterocycles from easily available carboxylic acid derivatives and o-substituted anilines. This transformation represents a widely applicable protocol to N-heterocycles using biofriendly iron as a catalyst in combination with molecular oxygen or air as the sole oxidant.