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Issue 19, 2015
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Viedma ripening: a reliable crystallisation method to reach single chirality

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Abstract

Crystallisation processes have evolved to practical methods that allow isolation of an enantiopure product in high yield. Viedma ripening in particular enables access to enantiopure products in a reliable way, simply through grinding of crystals in a solution. This tutorial review covers the basic principles behind asymmetric crystallisation processes, with an emphasis on Viedma ripening, and shows that to date many novel organic molecules can be obtained in enantiopure solid form.

Graphical abstract: Viedma ripening: a reliable crystallisation method to reach single chirality

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Publication details

The article was received on 03 Mar 2015 and first published on 13 Jul 2015


Article type: Tutorial Review
DOI: 10.1039/C5CS00196J
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Chem. Soc. Rev., 2015,44, 6723-6732
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    Viedma ripening: a reliable crystallisation method to reach single chirality

    L. Sögütoglu, R. R. E. Steendam, H. Meekes, E. Vlieg and F. P. J. T. Rutjes, Chem. Soc. Rev., 2015, 44, 6723
    DOI: 10.1039/C5CS00196J

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