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Issue 35, 2015
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Novel olfactory ligands via terpene synthases

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Abstract

A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

Graphical abstract: Novel olfactory ligands via terpene synthases

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Publication details

The article was received on 03 Mar 2015, accepted on 30 Mar 2015 and first published on 07 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC01814E
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Chem. Commun., 2015,51, 7550-7553
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    Novel olfactory ligands via terpene synthases

    S. Touchet, K. Chamberlain, C. M. Woodcock, D. J. Miller, M. A. Birkett, J. A. Pickett and R. K. Allemann, Chem. Commun., 2015, 51, 7550
    DOI: 10.1039/C5CC01814E

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